BNCT now clinically convenient with SUMITOMO's cyclotron
Clinical trials show important patient benefits
BNCT: Boron Neutron Capture Therapy — boron reacts with thermal neutrons. The NeuCure BNCT-system by SHI has approval as medical device in Japan after several years of clinical trials. It is the only clinically operational commercial BNCT system today
Bragg Peak: Dose peak at the end of the range of the charged particle beam. Used to optimize dose distribution of proton and light ion beams. More about Bragg Peak.
Cyclotron: Isochronous cyclotrons are designed to emit a steady particle beam with high energy and high current.
Only beams hitting the target are effective
ESS: Energy Selection System, AKA Degrader comprises of energy degrader and beam purification bend before the nozzle. Determines the energy i.e. depth of the Bragg Peak.
Fast pencil beam scanning
Accurate fast dose delivery from all angels
Gantry: Structure to rotate a beamline to allow ideally 360 degrees of treatment angels. The Gantry holds bending magnets and nozzle to deliver radiation precisely.
IMT: Integrated Medical Technologies Inc. makes nice phantoms and QA tools. See imtqa.com.
LIONESS: Light ION Energy Selection System — Energy selection system for charged particles from a cyclotron. Adjusts range of different light ion beams’ Bragg Peak.
See what you treat
Dose Escalation is possible and safe when visibility is really good
Light Ions: In particle therapy.
MeV: Kinetic energy measured in MegaelectronVolts.
MR-Linac: Combining 8 FPS MR cine during treatments with sharp radiation beams, the MRIdian Linac from ViewRay is used to treat moving targets in critical locations with high doses.
NEUCURE: First and only commercially available (in Japan) clinical BNCT product consist of a cyclotron accelerator and beryllium target from SUMITOMO, boron compound for injection by Stella Pharma, and RayStation TPS from Raysearch.
Maximize dose to target, minmimize dose to surrounding healthy tissue
Greater precision leads to better cures and fewer complications
OAR: Organs At Risk — Avoidance structures in treatment planning.
OIS: Oncology Information System = patient data archive and network.
Alpha, Gamma, X-rays/photons, neutrons, protons, helium
Photons / X-Rays, are used in conventional radiotherapy with linear accelerators.
Protons, Proton Therapy is a specialized sub-discipline of radiation therapy and radiosurgery, offering the dosimetric advantages of the Bragg Peak .
PSI: Paul Scherrer Institute in Villigen near Zurich, Switzerland.
Quality Assurance and Quality Control
Missing the target is not an option. Doublecheck!
QA and QC: Rigorous Quality Assurance and Quality Control are key to accurate and safe delivery of tumoricidal radiation doses. The phantoms from IMTQA do a great job as pseudo patients for end to end verification of dose deliveries.
Singularily superior superconducting systems
SUMITOMO also makes the cryocoolers for major medical magnets
SOBP: Spread Out Bragg Peak = achieved by superposition of proton beams with varying energy.
SRS: Stereotactic radiosurgery of the brain, head and neck. High precision, high dose, single fraction or few fractions.
Superconducting: So cool that there is no resistance.
Short but loaded
3 letters with meaning
TSL — The Svedberg Laboratory: Research particle accelerator at Uppsala University 1951-2016. The first animal experiments with stereotactic radiosurgery, and the first human cancer treatments with proton therapy were performed at the Svedberg Laboratory using the Gustav Werner cyclotron in 1957.
TLA: Three letter acronym — like TSL, SRS, ESS, MRL, PSI, TPS, ZAP, SHI, OIS, OAR, MeV,MRI, PET, CIA, FBI, FAQ. LMT (Lioness MedTech), TSS.
TSS — Training Support Specialists: Clinical and technical specialist training ensures smooth and efficient ramp-up and operations of your new precision radiation technology.
SMART DOSE DISTRIBUTIONS
MONTE CARLO TREATMENT PLANNING
TPS: Treatment Planning System = computerized calculation of the dose distribution and development of treatment technique and strategy. Based on CT and MRI images and dose optimization and calculation algorithms.
No vault, no cobalt
ZAP-X: Futuristic self-shielded new radiosurgery system with 3 MV linac. Design to spread radiosurgery to benefit more patients.