BNCT - Boron Neutron Capture Therapy

BNCT is a cell-selective therapy that combines a boron drug with a neutron beam.

 

Introduction to BNCT

BNCT aiming to treat refractory cancer

The treatment of cancers that are difficult to manage with conventional therapies, such as recurrent cancers, poses a significant challenge in modern clinical oncology. For instance, if cancer recurs after radiotherapy, administering another round of radiotherapy is problematic, and treatment options become limited. BNCT has been studied since the 1950s with the aim of treating recurrent, invasive, and refractory cancer.

BNCT system using an accelerator

In the past, BNCT required a nuclear reactor for its neutron source, which hindered its widespread adoption. However, with advancements in medical accelerator technology, a BNCT system that can be installed in hospitals has been developed. Starting in 2020, this BNCT system is now covered by insurance, marking a major step toward its widespread use.

Principle of BNCT

· Boron agents for BNCT selectively accumulate in cancer cells.

· At neutron irradiation, the boron in the tumor target captures neutrons and splits into alpha particles and 7Li nuclei in the cancer cells.

· The alpha and lithium particles are highly ionizing and damage the DNA of the cancer cells locally.

Features

Cancer cells are selectively destroyed with BNCT, thus reducing damage to normal cells.

BNCT can be applied to areas that have already been irradiated before.

BNCT requires only one or two sessions of radiation.

Treatment can be completed in a short period of time.

Workflow

A treatment plan is created with the BNCT treatment planning system.

The boron drug for BNCT is administered to the patient.

The patient is positioned and immobilized within the BNCT system.

The patient is positioned and immobilized within the BNCT system.

The BNCT system irradiates the patient with neutrons.

Hospitals where BNCT is currently available

Southern Tohoku BNCT Research Center

Fukushima, Japan

Osaka Medical College Kansai BNCT Joint Medical Center

Osaka, Japan

We use cookies to improve the user experience and gather anonymous visitor statistics. By using our website, you agree to the use of cookies.

I agree.