RefleXion-X1

RefleXion Clinical

Bone

Shirvani SM, Huntzinger CJ, Melcher T, Olcott PD, Voronenko Y, Bartlett-Roberto J et al. Biology-guided radiotherapy: redefining the role of radiotherapy in metastatic cancer. Br J Radiol 2020;94:20200873. DOI: 10.1259/bjr.20200873

Head & Neck

Shi M, Simiele E, Han B, Pham D, Palomares P, Aguirre M, et al. First-year experience of stereotactic body radiation therapy/Intensity Modulated Radiation Therapy treatment using a novel biology-guided radiation therapy machine. Adv Radiat Oncol 2024;9:101300. DOI: 10.1016/j.adro.2023.101300

Prostate

Lancia A, Ingrosso G, Detti B, Festa E, Bonzano E, Linguanti F, et al. Biology-guided radiotherapy in metastatic prostate cancer: time to push the envelope? Front Oncol 2024;14:1455428. DOI: 10.3389/fonc.2024.1455428

RefleXion Technology

Technology

Oderinde OM, Shirvani SM, Olcott PD, Kuduvalli G, Mazin S, Larkin D. The technical design and concept of a PET/CT linac for biology-guided radiotherapy. Clin Transl Radiat Oncol 2021;29:106-112. DOI: 10.1016/j.ctro.2021.04.003

Dosimetry

Watkins TW, Yang R, Han C, Liu A, Surucu M, Kovalchuk N, et al. Commissioning of the RefleXion X1 linear accelerator and development of a consensus reference beam model. Med Phys 2025;52:e70173. DOI: 10.1002/mp.70173

Surucu M, Ashraf MR, Romero IO, Zalavari LT, Pham D, Vitzthum LK, et al. Commissioning of a novel PET-Linac for biology-guided radiotherapy (BgRT). Med Phys 2024;51:4389-4401. DOI: 10.1002/mp.17114

Treatment planning

Simiele E, Capaldi D, Breitkreutz D, Han B, Yeung T, White J, et al. Treatment planning system commissioning of the first clinical biology-guided radiotherapy machine. J Appl Clin Med Phys 2022;23:e13638. DOI: 10.1002/acm2.13638